diff --git a/src/coreclr/gcinfo/gcinfoencoder.cpp b/src/coreclr/gcinfo/gcinfoencoder.cpp
index 2a0636e11dbb7e..2855b27104e159 100644
--- a/src/coreclr/gcinfo/gcinfoencoder.cpp
+++ b/src/coreclr/gcinfo/gcinfoencoder.cpp
@@ -720,7 +720,8 @@ template <typename GcInfoEncoding> void TGcInfoEncoder<GcInfoEncoding>::SetStack
     _ASSERTE(GcInfoEncoding::DENORMALIZE_STACK_BASE_REGISTER(GcInfoEncoding::NORMALIZE_STACK_BASE_REGISTER(regNum)) == regNum);
     _ASSERTE( m_StackBaseRegister == NO_STACK_BASE_REGISTER || m_StackBaseRegister == regNum );
 #if defined(TARGET_LOONGARCH64)
-    assert(regNum == 3 || 22 == regNum);
+    // Note that the regNum == 0 only occurs under interpreter.
+    assert(regNum == 3 || 22 == regNum || 0 == regNum);
 #elif defined(TARGET_RISCV64)
     assert(regNum == 2 || 8 == regNum);
 #endif
@@ -961,7 +962,8 @@ template <typename GcInfoEncoding> void TGcInfoEncoder<GcInfoEncoding>::Build()
         // Slim encoding means nothing special, partially interruptible, maybe a default frame register
         GCINFO_WRITE(m_Info1, 0, 1, FlagsSize); // Slim encoding
 #if defined(TARGET_LOONGARCH64)
-        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister);
+        // Note that the m_StackBaseRegister == 0 only occurs under interpreter.
+        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister || 0 == m_StackBaseRegister);
 #elif defined(TARGET_RISCV64)
         assert(m_StackBaseRegister == 8 || 2 == m_StackBaseRegister);
 #endif
@@ -976,7 +978,8 @@ template <typename GcInfoEncoding> void TGcInfoEncoder<GcInfoEncoding>::Build()
         GCINFO_WRITE(m_Info1, 0 /* unused - was hasPSPSymStackSlot */, 1, FlagsSize);
         GCINFO_WRITE(m_Info1, m_contextParamType, 2, FlagsSize);
 #if defined(TARGET_LOONGARCH64)
-        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister);
+        // Note that the m_StackBaseRegister == 0 only occurs under interpreter.
+        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister || 0 == m_StackBaseRegister);
 #elif defined(TARGET_RISCV64)
         assert(m_StackBaseRegister == 8 || 2 == m_StackBaseRegister);
 #endif
@@ -1060,7 +1063,8 @@ template <typename GcInfoEncoding> void TGcInfoEncoder<GcInfoEncoding>::Build()
     if(!slimHeader && (m_StackBaseRegister != NO_STACK_BASE_REGISTER))
     {
 #if defined(TARGET_LOONGARCH64)
-        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister);
+        // Note that the m_StackBaseRegister == 0 only occurs under interpreter.
+        assert(m_StackBaseRegister == 22 || 3 == m_StackBaseRegister || 0 == m_StackBaseRegister);
 #elif defined(TARGET_RISCV64)
         assert(m_StackBaseRegister == 8 || 2 == m_StackBaseRegister);
 #endif
diff --git a/src/coreclr/vm/loongarch64/asmhelpers.S b/src/coreclr/vm/loongarch64/asmhelpers.S
index c4dce79a61fbde..c5ec464e7d3a86 100644
--- a/src/coreclr/vm/loongarch64/asmhelpers.S
+++ b/src/coreclr/vm/loongarch64/asmhelpers.S
@@ -1201,7 +1201,7 @@ Load_Ref A7, $a7
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetVoid, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a4, $fp, 16
     sub.d $sp, $sp, $a3
     ori $t2, $a0, 0
@@ -1222,7 +1222,7 @@ NESTED_END CallJittedMethodRetVoid, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetBuff, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a4, $fp, 16
     sub.d $sp, $sp, $a3
     ori $t2, $a0, 0
@@ -1244,7 +1244,7 @@ NESTED_END CallJittedMethodRetBuff, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetI1, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1271,7 +1271,7 @@ NESTED_END CallJittedMethodRetI1, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetI2, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1298,7 +1298,7 @@ NESTED_END CallJittedMethodRetI2, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetU1, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1325,7 +1325,7 @@ NESTED_END CallJittedMethodRetU1, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetU2, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1352,7 +1352,7 @@ NESTED_END CallJittedMethodRetU2, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetI8, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1376,7 +1376,7 @@ NESTED_END CallJittedMethodRetI8, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetDouble, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1400,7 +1400,7 @@ NESTED_END CallJittedMethodRetDouble, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetFloat, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1424,7 +1424,7 @@ NESTED_END CallJittedMethodRetFloat, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRet2I8, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1449,7 +1449,7 @@ NESTED_END CallJittedMethodRet2I8, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRet2Double, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1474,7 +1474,7 @@ NESTED_END CallJittedMethodRet2Double, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRet2Float, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1499,7 +1499,7 @@ NESTED_END CallJittedMethodRet2Float, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetFloatInt, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1524,7 +1524,7 @@ NESTED_END CallJittedMethodRetFloatInt, _TEXT
 // $a3 - stack arguments size (properly aligned)
 // $a4 - address of continuation return value
 NESTED_ENTRY CallJittedMethodRetIntFloat, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, -32
+    PROLOG_SAVE_REG_PAIR_INDEXED 22, 1, 32
     st.d $a2, $fp, 16
     st.d $a4, $fp, 24
     sub.d $sp, $sp, $a3
@@ -1548,19 +1548,18 @@ NESTED_ENTRY InterpreterStub, _TEXT, NoHandler
     PROLOG_WITH_TRANSITION_BLOCK
 
     // IR bytecode address
-    ori $t6, $METHODDESC_REGISTER, 0
+    ori $s0, $METHODDESC_REGISTER, 0
 
     INLINE_GETTHREAD $t5 // thrashes $a0
     beq $t5, $zero, LOCAL_LABEL(NoManagedThreadOrCallStub)
 
-    li.d $t1, OFFSETOF__Thread__m_pInterpThreadContext
-    add.d $t1, $t5, $t1
+    addi.d $t1, $t5, OFFSETOF__Thread__m_pInterpThreadContext
     ld.d $t4, $t1, 0
     bne $t4, $zero, LOCAL_LABEL(HaveInterpThreadContext)
 
 LOCAL_LABEL(NoManagedThreadOrCallStub):
     addi.d $a0, $sp, __PWTB_TransitionBlock
-    ori $a1, $t6, 0
+    ori $a1, $s0, 0
     bl C_FUNC(GetInterpThreadContextWithPossiblyMissingThreadOrCallStub)
     ori $t4, $a0, 0
 
@@ -1569,13 +1568,12 @@ LOCAL_LABEL(HaveInterpThreadContext):
     RESTORE_ARGUMENT_REGISTERS $sp, __PWTB_ArgumentRegisters
     RESTORE_FLOAT_ARGUMENT_REGISTERS $sp, __PWTB_FloatArgumentRegisters
 
-    ld.d $t3, $t6, 0 // InterpMethod*
+    ld.d $t3, $s0, 0 // InterpMethod*
     ld.d $t3, $t3, OFFSETOF__InterpMethod__pCallStub
     beq $t3, $zero, LOCAL_LABEL(NoManagedThreadOrCallStub)
-    li.d $t2, OFFSETOF__CallStubHeader__Routines
-    add.d $t2, $t3, $t2
+    addi.d $t2, $t3, OFFSETOF__CallStubHeader__Routines
     ld.d $t3, $t4, OFFSETOF__InterpThreadContext__pStackPointer
-    // $t6 contains IR bytecode address
+    // $s0 contains IR bytecode address
     // Copy the arguments to the interpreter stack, invoke the InterpExecMethod and load the return value
     ld.d $t4, $t2, 0
     addi.d $t2, $t2, 8
@@ -1588,10 +1586,10 @@ LOCAL_LABEL(HaveInterpThreadContext):
 NESTED_END InterpreterStub, _TEXT
 
 NESTED_ENTRY InterpreterStubRetVoid, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     EPILOG_RESTORE_REG_PAIR_INDEXED   22, 1,   16
@@ -1599,10 +1597,10 @@ NESTED_ENTRY InterpreterStubRetVoid, _TEXT, NoHandler
 NESTED_END InterpreterStubRetVoid, _TEXT
 
 NESTED_ENTRY InterpreterStubRetI8, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     ld.d $a0, $a0, 0
@@ -1611,10 +1609,10 @@ NESTED_ENTRY InterpreterStubRetI8, _TEXT, NoHandler
 NESTED_END InterpreterStubRetI8, _TEXT
 
 NESTED_ENTRY InterpreterStubRetDouble, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     fld.d $fa0, $a0, 0
@@ -1623,21 +1621,21 @@ NESTED_ENTRY InterpreterStubRetDouble, _TEXT, NoHandler
 NESTED_END InterpreterStubRetDouble, _TEXT
 
 NESTED_ENTRY InterpreterStubRetBuff, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     ori $a2, $a0, 0        // save caller's return buffer in $a2
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0        // the IR bytecode pointer (x19)
+    ori $a1, $s0, 0        // the IR bytecode pointer (x19)
     bl C_FUNC(ExecuteInterpretedMethod)
     EPILOG_RESTORE_REG_PAIR_INDEXED   22, 1, 16
     EPILOG_RETURN
 NESTED_END InterpreterStubRetBuff, _TEXT
 
 NESTED_ENTRY InterpreterStubRet2I8, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     ld.d $a1, $a0, 8
@@ -1647,10 +1645,10 @@ NESTED_ENTRY InterpreterStubRet2I8, _TEXT, NoHandler
 NESTED_END InterpreterStubRet2I8, _TEXT
 
 NESTED_ENTRY InterpreterStubRet2Double, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     fld.d $fa0, $a0, 0
@@ -1660,10 +1658,10 @@ NESTED_ENTRY InterpreterStubRet2Double, _TEXT, NoHandler
 NESTED_END InterpreterStubRet2Double, _TEXT
 
 NESTED_ENTRY InterpreterStubRetFloat, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     fld.s $fa0, $a0, 0
@@ -1672,10 +1670,10 @@ NESTED_ENTRY InterpreterStubRetFloat, _TEXT, NoHandler
 NESTED_END InterpreterStubRetFloat, _TEXT
 
 NESTED_ENTRY InterpreterStubRet2Float, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     fld.s $fa0, $a0, 0
@@ -1685,10 +1683,10 @@ NESTED_ENTRY InterpreterStubRet2Float, _TEXT, NoHandler
 NESTED_END InterpreterStubRet2Float, _TEXT
 
 NESTED_ENTRY InterpreterStubRetFloatInt, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     fld.d $fa0, $a0, 0
@@ -1698,10 +1696,10 @@ NESTED_ENTRY InterpreterStubRetFloatInt, _TEXT, NoHandler
 NESTED_END InterpreterStubRetFloatInt, _TEXT
 
 NESTED_ENTRY InterpreterStubRetIntFloat, _TEXT, NoHandler
-    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, -16
+    PROLOG_SAVE_REG_PAIR_INDEXED   22, 1, 16
     // The +16 is for the $fp, $ra above
     addi.d $a0, $sp, __PWTB_TransitionBlock + 16
-    ori $a1, $t6, 0 // the IR bytecode pointer
+    ori $a1, $s0, 0 // the IR bytecode pointer
     ori $a2, $zero, 0
     bl C_FUNC(ExecuteInterpretedMethod)
     ld.d $a1, $a0, 0