diff --git a/CHANGELOG.adoc b/CHANGELOG.adoc
index bbfe750876..5135de4118 100644
--- a/CHANGELOG.adoc
+++ b/CHANGELOG.adoc
@@ -22,6 +22,7 @@ Release with new features and bugfixes:
 * https://github.com/devonfw/IDEasy/issues/1853[#1853]: Add ARM releases for VSCode on Mac
 * https://github.com/devonfw/IDEasy/issues/797[#797]: Use system unzip on macOS to preserve symlinks in ZIP extraction
 * https://github.com/devonfw/IDEasy/issues/1723[#1723]: Add commandlet for GitHub Copilot CLI
+* https://github.com/devonfw/IDEasy/pull/1885[#1885]: Add per-project uv tool isolation using UV_TOOL_DIR and UV_TOOL_BIN_DIR
 * https://github.com/devonfw/IDEasy/issues/861[#861]: Fix install of pgadmin throws IllegalStateException when the install wizard starts
 * https://github.com/devonfw/IDEasy/issues/1844[#1844]: VSCode plugin installation progress freezing
 * https://github.com/devonfw/IDEasy/issues/1456[#1456]: Uninstall via Windows settings not working
diff --git a/cli/src/main/java/com/devonfw/tools/ide/tool/python/Python.java b/cli/src/main/java/com/devonfw/tools/ide/tool/python/Python.java
index caa38b5a3e..3af6dd2fa1 100644
--- a/cli/src/main/java/com/devonfw/tools/ide/tool/python/Python.java
+++ b/cli/src/main/java/com/devonfw/tools/ide/tool/python/Python.java
@@ -66,6 +66,8 @@ public void setEnvironment(EnvironmentContext environmentContext, ToolInstallati
 
     super.setEnvironment(environmentContext, toolInstallation, additionalInstallation);
     environmentContext.withEnvVar("VIRTUAL_ENV", toolInstallation.rootDir().toString());
+    environmentContext.withEnvVar("UV_TOOL_DIR", toolInstallation.rootDir().resolve("tools").toString());
+    environmentContext.withEnvVar("UV_TOOL_BIN_DIR", toolInstallation.binDir().toString());
   }
 
   @Override
diff --git a/cli/src/main/java/com/devonfw/tools/ide/tool/uv/Uv.java b/cli/src/main/java/com/devonfw/tools/ide/tool/uv/Uv.java
index 4efdac6c65..9665353f4d 100644
--- a/cli/src/main/java/com/devonfw/tools/ide/tool/uv/Uv.java
+++ b/cli/src/main/java/com/devonfw/tools/ide/tool/uv/Uv.java
@@ -6,11 +6,13 @@
 
 import com.devonfw.tools.ide.common.Tag;
 import com.devonfw.tools.ide.context.IdeContext;
+import com.devonfw.tools.ide.process.EnvironmentContext;
 import com.devonfw.tools.ide.process.ProcessContext;
 import com.devonfw.tools.ide.process.ProcessMode;
 import com.devonfw.tools.ide.process.ProcessResult;
 import com.devonfw.tools.ide.tool.LocalToolCommandlet;
 import com.devonfw.tools.ide.tool.ToolCommandlet;
+import com.devonfw.tools.ide.tool.ToolInstallation;
 import com.devonfw.tools.ide.version.VersionIdentifier;
 
 /**
@@ -42,4 +44,12 @@ public void installPython(Path installationPath, VersionIdentifier resolvedVersi
     ProcessResult result = runTool(processContext, ProcessMode.DEFAULT_CAPTURE, List.of("venv", "--python", resolvedVersion.toString()));
     assert result.isSuccessful();
   }
+  @Override
+  public void setEnvironment(EnvironmentContext environmentContext, ToolInstallation toolInstallation, boolean additionalInstallation) {
+
+    super.setEnvironment(environmentContext, toolInstallation, additionalInstallation);
+    Path pythonPath = this.context.getSoftwarePath().resolve("python");
+    environmentContext.withEnvVar("UV_TOOL_DIR", pythonPath.resolve("tools").toString());
+    environmentContext.withEnvVar("UV_TOOL_BIN_DIR", pythonPath.resolve("bin").toString());
+  }
 }
diff --git a/cli/src/test/java/com/devonfw/tools/ide/tool/python/PythonTest.java b/cli/src/test/java/com/devonfw/tools/ide/tool/python/PythonTest.java
new file mode 100644
index 0000000000..5f0139d68e
--- /dev/null
+++ b/cli/src/test/java/com/devonfw/tools/ide/tool/python/PythonTest.java
@@ -0,0 +1,42 @@
+package com.devonfw.tools.ide.tool.python;
+
+import java.nio.file.Path;
+import java.util.HashMap;
+import java.util.Map;
+
+import org.junit.jupiter.api.Test;
+
+import com.devonfw.tools.ide.context.AbstractIdeContextTest;
+import com.devonfw.tools.ide.context.IdeTestContext;
+import com.devonfw.tools.ide.environment.EnvironmentVariablesType;
+import com.devonfw.tools.ide.environment.VariableLine;
+import com.devonfw.tools.ide.environment.VariableSource;
+import com.devonfw.tools.ide.os.WindowsPathSyntax;
+import com.devonfw.tools.ide.process.EnvironmentVariableCollectorContext;
+import com.devonfw.tools.ide.tool.ToolInstallation;
+import com.devonfw.tools.ide.version.VersionIdentifier;
+
+/**
+ * Test of {@link Python}.
+ */
+public class PythonTest extends AbstractIdeContextTest {
+
+  @Test
+  public void testSetEnvironment() {
+
+    // arrange
+    IdeTestContext context = newContext(PROJECT_BASIC);
+    Python python = new Python(context);
+    Path rootDir = context.getSoftwarePath().resolve("python");
+    ToolInstallation toolInstallation = new ToolInstallation(rootDir, rootDir, rootDir.resolve("bin"), VersionIdentifier.of("3.12.0"), true);
+    Map<String, VariableLine> variables = new HashMap<>();
+    EnvironmentVariableCollectorContext environmentContext = new EnvironmentVariableCollectorContext(variables, new VariableSource(EnvironmentVariablesType.WORKSPACE, null), WindowsPathSyntax.MSYS);
+
+    // act
+    python.setEnvironment(environmentContext, toolInstallation, false);
+
+    // assert
+    assertThat(Path.of(variables.get("UV_TOOL_DIR").getValue())).isEqualTo(toolInstallation.rootDir().resolve("tools"));
+    assertThat(Path.of(variables.get("UV_TOOL_BIN_DIR").getValue())).isEqualTo(toolInstallation.binDir());
+  }
+}
diff --git a/cli/src/test/java/com/devonfw/tools/ide/tool/uv/UvTest.java b/cli/src/test/java/com/devonfw/tools/ide/tool/uv/UvTest.java
new file mode 100644
index 0000000000..984f7bd4b6
--- /dev/null
+++ b/cli/src/test/java/com/devonfw/tools/ide/tool/uv/UvTest.java
@@ -0,0 +1,43 @@
+package com.devonfw.tools.ide.tool.uv;
+
+import java.nio.file.Path;
+import java.util.HashMap;
+import java.util.Map;
+
+import org.junit.jupiter.api.Test;
+
+import com.devonfw.tools.ide.context.AbstractIdeContextTest;
+import com.devonfw.tools.ide.context.IdeTestContext;
+import com.devonfw.tools.ide.environment.EnvironmentVariablesType;
+import com.devonfw.tools.ide.environment.VariableLine;
+import com.devonfw.tools.ide.environment.VariableSource;
+import com.devonfw.tools.ide.os.WindowsPathSyntax;
+import com.devonfw.tools.ide.process.EnvironmentVariableCollectorContext;
+import com.devonfw.tools.ide.tool.ToolInstallation;
+import com.devonfw.tools.ide.version.VersionIdentifier;
+
+/**
+ * Test of {@link Uv}.
+ */
+public class UvTest extends AbstractIdeContextTest {
+
+  @Test
+  public void testSetEnvironment() {
+
+    // arrange
+    IdeTestContext context = newContext(PROJECT_BASIC);
+    Uv uv = new Uv(context);
+    Path rootDir = context.getSoftwarePath().resolve("uv");
+    ToolInstallation toolInstallation = new ToolInstallation(rootDir, rootDir, rootDir, VersionIdentifier.of("0.1.0"), true);
+    Map<String, VariableLine> variables = new HashMap<>();
+    EnvironmentVariableCollectorContext environmentContext = new EnvironmentVariableCollectorContext(variables, new VariableSource(EnvironmentVariablesType.WORKSPACE, null), WindowsPathSyntax.MSYS);
+
+    // act
+    uv.setEnvironment(environmentContext, toolInstallation, false);
+
+    // assert
+    Path expectedPythonPath = context.getSoftwarePath().resolve("python");
+    assertThat(Path.of(variables.get("UV_TOOL_DIR").getValue())).isEqualTo(expectedPythonPath.resolve("tools"));
+    assertThat(Path.of(variables.get("UV_TOOL_BIN_DIR").getValue())).isEqualTo(expectedPythonPath.resolve("bin"));
+  }
+}