diff --git a/pylabrobot/thermocycling/backend.py b/pylabrobot/thermocycling/backend.py
index cf0955364ae..2ba239415e9 100644
--- a/pylabrobot/thermocycling/backend.py
+++ b/pylabrobot/thermocycling/backend.py
@@ -53,18 +53,10 @@ async def run_protocol(self, protocol: Protocol, block_max_volume: float):
   async def get_block_current_temperature(self) -> List[float]:
     """Get the current block temperature zones in °C."""
 
-  @abstractmethod
-  async def get_block_target_temperature(self) -> List[float]:
-    """Get the block target temperature zones in °C. May raise RuntimeError if no target is set."""
-
   @abstractmethod
   async def get_lid_current_temperature(self) -> List[float]:
     """Get the current lid temperature zones in °C."""
 
-  @abstractmethod
-  async def get_lid_target_temperature(self) -> List[float]:
-    """Get the lid target temperature zones in °C. May raise RuntimeError if no target is set."""
-
   @abstractmethod
   async def get_lid_open(self) -> bool:
     """Return ``True`` if the lid is open."""
@@ -85,14 +77,6 @@ async def get_hold_time(self) -> float:
   async def get_current_cycle_index(self) -> int:
     """Get the zero-based index of the current cycle."""
 
-  @abstractmethod
-  async def get_total_cycle_count(self) -> int:
-    """Get the total cycle count."""
-
   @abstractmethod
   async def get_current_step_index(self) -> int:
     """Get the zero-based index of the current step within the cycle."""
-
-  @abstractmethod
-  async def get_total_step_count(self) -> int:
-    """Get the total number of steps in the current cycle."""
diff --git a/pylabrobot/thermocycling/chatterbox.py b/pylabrobot/thermocycling/chatterbox.py
index 1c45e40752d..8d45ceede97 100644
--- a/pylabrobot/thermocycling/chatterbox.py
+++ b/pylabrobot/thermocycling/chatterbox.py
@@ -151,33 +151,17 @@ async def get_hold_time(self) -> float:
   async def get_current_cycle_index(self) -> int:
     return 1
 
-  async def get_total_cycle_count(self) -> int:
-    return 1
-
   async def get_current_step_index(self) -> int:
     # If the profile is "running", it means the simulation hasn't happened yet.
     # The moment get_hold_time is called, it will complete instantly.
     return self._state.total_steps if not self._state.is_profile_running else 1
 
-  async def get_total_step_count(self) -> int:
-    return self._state.total_steps
-
   async def get_block_current_temperature(self) -> List[float]:
     return self._state.block_temp
 
-  async def get_block_target_temperature(self) -> List[float]:
-    if self._state.block_target is None:
-      raise RuntimeError("Block target temperature is not set. Is a cycle running?")
-    return self._state.block_target
-
   async def get_lid_current_temperature(self) -> List[float]:
     return self._state.lid_temp
 
-  async def get_lid_target_temperature(self) -> List[float]:
-    if self._state.lid_target is None:
-      raise RuntimeError("Lid target temperature is not set. Is a cycle running?")
-    return self._state.lid_target
-
   async def get_lid_open(self) -> bool:
     return self._state.lid_open
 
diff --git a/pylabrobot/thermocycling/inheco/odtc_backend.py b/pylabrobot/thermocycling/inheco/odtc_backend.py
index 84e1b69665b..3e9c8b5a8bb 100644
--- a/pylabrobot/thermocycling/inheco/odtc_backend.py
+++ b/pylabrobot/thermocycling/inheco/odtc_backend.py
@@ -184,9 +184,6 @@ async def get_block_current_temperature(self) -> List[float]:
     temps = await self.get_sensor_data()
     return [temps.get("Mount", 0.0)]
 
-  async def get_block_target_temperature(self) -> List[float]:
-    raise NotImplementedError()
-
   async def get_block_status(self) -> BlockStatus:
     raise NotImplementedError()
 
@@ -208,9 +205,6 @@ async def get_lid_current_temperature(self) -> List[float]:
     temps = await self.get_sensor_data()
     return [temps.get("Lid", 0.0)]
 
-  async def get_lid_target_temperature(self) -> List[float]:
-    raise NotImplementedError()
-
   # -------------------------------------------------------------------------
   # Protocol
   # -------------------------------------------------------------------------
@@ -382,11 +376,5 @@ async def get_hold_time(self) -> float:
   async def get_current_cycle_index(self) -> int:
     raise NotImplementedError()
 
-  async def get_total_cycle_count(self) -> int:
-    raise NotImplementedError()
-
   async def get_current_step_index(self) -> int:
     raise NotImplementedError()
-
-  async def get_total_step_count(self) -> int:
-    raise NotImplementedError()
diff --git a/pylabrobot/thermocycling/opentrons_backend.py b/pylabrobot/thermocycling/opentrons_backend.py
index 039708f348f..34df30a87eb 100644
--- a/pylabrobot/thermocycling/opentrons_backend.py
+++ b/pylabrobot/thermocycling/opentrons_backend.py
@@ -126,22 +126,9 @@ def _find_module(self) -> dict:
   async def get_block_current_temperature(self) -> List[float]:
     return [cast(float, self._find_module()["currentTemperature"])]
 
-  async def get_block_target_temperature(self) -> List[float]:
-    target_temp = self._find_module().get("targetTemperature")
-    if target_temp is None:
-      raise RuntimeError("Block target temperature is not set. is a cycle running?")
-    return [cast(float, target_temp)]
-
   async def get_lid_current_temperature(self) -> List[float]:
     return [cast(float, self._find_module()["lidTemperature"])]
 
-  async def get_lid_target_temperature(self) -> List[float]:
-    """Get the lid target temperature in °C. Raises RuntimeError if no target is active."""
-    target_temp = self._find_module().get("lidTargetTemperature")
-    if target_temp is None:
-      raise RuntimeError("Lid target temperature is not set. is a cycle running?")
-    return [cast(float, target_temp)]
-
   async def get_lid_open(self) -> bool:
     return cast(str, self._find_module()["lidStatus"]) == "open"
 
@@ -185,10 +172,6 @@ async def get_current_cycle_index(self) -> int:
 
     raise RuntimeError("Current cycle index is not available. Is a profile running?")
 
-  async def get_total_cycle_count(self) -> int:
-    # https://github.com/PyLabRobot/pylabrobot/issues/632
-    raise NotImplementedError('Opentrons "cycle" concept is not understood currently.')
-
   async def get_current_step_index(self) -> int:
     """Get the zero-based index of the current step from the Opentrons API."""
     # Opentrons API returns one-based, convert to zero-based
@@ -196,9 +179,3 @@ async def get_current_step_index(self) -> int:
     if step_index is None:
       raise RuntimeError("Current step index is not available. Is a profile running?")
     return cast(int, step_index) - 1
-
-  async def get_total_step_count(self) -> int:
-    total_steps = self._find_module().get("totalStepCount")
-    if total_steps is None:
-      raise RuntimeError("Total step count is not available. Is a profile running?")
-    return cast(int, total_steps)
diff --git a/pylabrobot/thermocycling/opentrons_backend_tests.py b/pylabrobot/thermocycling/opentrons_backend_tests.py
index c68460a991e..2f3cba3f2b1 100644
--- a/pylabrobot/thermocycling/opentrons_backend_tests.py
+++ b/pylabrobot/thermocycling/opentrons_backend_tests.py
@@ -98,17 +98,13 @@ async def test_getters_return_correct_data(self, mock_list_connected_modules):
     mock_list_connected_modules.return_value = [mock_data]
 
     assert await self.thermocycler_backend.get_block_current_temperature() == [25.5]
-    assert await self.thermocycler_backend.get_block_target_temperature() == [95.0]
     assert await self.thermocycler_backend.get_lid_current_temperature() == [37.1]
-    assert await self.thermocycler_backend.get_lid_target_temperature() == [105.0]
     assert await self.thermocycler_backend.get_lid_open() is True
     assert await self.thermocycler_backend.get_lid_status() == LidStatus.HOLDING_AT_TARGET
     assert await self.thermocycler_backend.get_block_status() == BlockStatus.HOLDING_AT_TARGET
     assert await self.thermocycler_backend.get_hold_time() == 12.0
     # assert await self.thermocycler_backend.get_current_cycle_index() == 1  # 2 - 1 = 1 (zero-based)
-    # assert await self.thermocycler_backend.get_total_cycle_count() == 10
     assert await self.thermocycler_backend.get_current_step_index() == 0  # 1 - 1 = 0 (zero-based)
-    assert await self.thermocycler_backend.get_total_step_count() == 3
 
   @patch("pylabrobot.thermocycling.opentrons_backend.list_connected_modules")
   async def test_get_hold_time_raises_if_not_running(self, mock_list_connected_modules):
diff --git a/pylabrobot/thermocycling/opentrons_backend_usb.py b/pylabrobot/thermocycling/opentrons_backend_usb.py
index 41daf9a002c..2ecb246e8f9 100644
--- a/pylabrobot/thermocycling/opentrons_backend_usb.py
+++ b/pylabrobot/thermocycling/opentrons_backend_usb.py
@@ -281,25 +281,11 @@ async def get_block_current_temperature(self) -> List[float]:
     plate_temp = await self._driver.get_plate_temperature()
     return [plate_temp.current]
 
-  async def get_block_target_temperature(self) -> List[float]:
-    assert self._driver is not None
-    plate_temp = await self._driver.get_plate_temperature()
-    if plate_temp.target is not None:
-      return [plate_temp.target]
-    raise RuntimeError("Block target temperature is not set.")
-
   async def get_lid_current_temperature(self) -> List[float]:
     assert self._driver is not None
     lid_temp = await self._driver.get_lid_temperature()
     return [lid_temp.current]
 
-  async def get_lid_target_temperature(self) -> List[float]:
-    assert self._driver is not None
-    lid_temp = await self._driver.get_lid_temperature()
-    if lid_temp.target is not None:
-      return [lid_temp.target]
-    raise RuntimeError("Lid target temperature is not set.")
-
   async def get_lid_open(self) -> bool:
     """Return True if the lid is open."""
     assert self._driver is not None
@@ -326,11 +312,5 @@ async def get_hold_time(self) -> float:
   async def get_current_cycle_index(self) -> int:
     return self._current_cycle_index if self._current_cycle_index is not None else 0
 
-  async def get_total_cycle_count(self) -> int:
-    return self._total_cycle_count if self._total_cycle_count is not None else 0
-
   async def get_current_step_index(self) -> int:
     return self._current_step_index if self._current_step_index is not None else 0
-
-  async def get_total_step_count(self) -> int:
-    return self._total_step_count if self._total_step_count is not None else 0
diff --git a/pylabrobot/thermocycling/thermo_fisher/thermo_fisher_thermocycler.py b/pylabrobot/thermocycling/thermo_fisher/thermo_fisher_thermocycler.py
index 86bab4c0e3d..9e0dbb0ef7d 100644
--- a/pylabrobot/thermocycling/thermo_fisher/thermo_fisher_thermocycler.py
+++ b/pylabrobot/thermocycling/thermo_fisher/thermo_fisher_thermocycler.py
@@ -1036,19 +1036,3 @@ async def get_lid_open(self, *args, **kwargs):
 
   async def get_lid_status(self, *args, **kwargs) -> LidStatus:
     raise NotImplementedError
-
-  async def get_lid_target_temperature(self, *args, **kwargs):
-    # deprecated
-    raise NotImplementedError
-
-  async def get_total_cycle_count(self, *args, **kwargs):
-    # deprecated
-    raise NotImplementedError
-
-  async def get_total_step_count(self, *args, **kwargs):
-    # deprecated
-    raise NotImplementedError
-
-  async def get_block_target_temperature(self, *args, **kwargs):
-    # deprecated
-    raise NotImplementedError
diff --git a/pylabrobot/thermocycling/thermocycler.py b/pylabrobot/thermocycling/thermocycler.py
index 622599d47a2..b602f4073ea 100644
--- a/pylabrobot/thermocycling/thermocycler.py
+++ b/pylabrobot/thermocycling/thermocycler.py
@@ -48,6 +48,11 @@ def __init__(
     )
     Machine.__init__(self, backend=backend)
     self.backend: ThermocyclerBackend = backend
+    self._block_target_temperature: Optional[List[float]] = None
+    self._lid_target_temperature: Optional[List[float]] = None
+    self._current_protocol: Optional[Protocol] = None
+    self._total_cycle_count: int = 0
+    self._total_step_count: int = 0
 
   async def open_lid(self, **backend_kwargs):
     return await self.backend.open_lid(**backend_kwargs)
@@ -61,6 +66,7 @@ async def set_block_temperature(self, temperature: List[float], **backend_kwargs
     Args:
       temperature: List of target temperatures in °C for multiple zones.
     """
+    self._block_target_temperature = list(temperature)
     return await self.backend.set_block_temperature(temperature, **backend_kwargs)
 
   async def set_lid_temperature(self, temperature: List[float], **backend_kwargs):
@@ -69,6 +75,7 @@ async def set_lid_temperature(self, temperature: List[float], **backend_kwargs):
     Args:
       temperature: List of target temperatures in °C for multiple zones.
     """
+    self._lid_target_temperature = list(temperature)
     return await self.backend.set_lid_temperature(temperature, **backend_kwargs)
 
   async def deactivate_block(self, **backend_kwargs):
@@ -96,6 +103,11 @@ async def run_protocol(self, protocol: Protocol, block_max_volume: float, **back
             f"Expected {num_zones}, got {len(step.temperature)} in step {i}."
           )
 
+    self._current_protocol = protocol
+    self._block_target_temperature = list(protocol.stages[0].steps[0].temperature)
+    self._total_cycle_count = sum(stage.repeats for stage in protocol.stages)
+    self._total_step_count = sum(len(stage.steps) * stage.repeats for stage in protocol.stages)
+
     return await self.backend.run_protocol(protocol, block_max_volume, **backend_kwargs)
 
   async def run_pcr_profile(
@@ -180,7 +192,9 @@ async def get_block_current_temperature(self, **backend_kwargs) -> List[float]:
 
   async def get_block_target_temperature(self, **backend_kwargs) -> List[float]:
     """Get the block's target temperature(s) (°C)."""
-    return await self.backend.get_block_target_temperature(**backend_kwargs)
+    if self._block_target_temperature is None:
+      raise RuntimeError("Block target temperature is not set.")
+    return self._block_target_temperature
 
   async def get_lid_current_temperature(self, **backend_kwargs) -> List[float]:
     """Get the current lid temperature(s) (°C)."""
@@ -188,7 +202,9 @@ async def get_lid_current_temperature(self, **backend_kwargs) -> List[float]:
 
   async def get_lid_target_temperature(self, **backend_kwargs) -> List[float]:
     """Get the lid's target temperature(s) (°C), if supported."""
-    return await self.backend.get_lid_target_temperature(**backend_kwargs)
+    if self._lid_target_temperature is None:
+      raise RuntimeError("Lid target temperature is not set.")
+    return self._lid_target_temperature
 
   async def get_lid_open(self, **backend_kwargs) -> bool:
     """Return ``True`` if the lid is open."""
@@ -212,15 +228,15 @@ async def get_current_cycle_index(self, **backend_kwargs) -> int:
 
   async def get_total_cycle_count(self, **backend_kwargs) -> int:
     """Get the total number of cycles."""
-    return await self.backend.get_total_cycle_count(**backend_kwargs)
+    return self._total_cycle_count
 
   async def get_current_step_index(self, **backend_kwargs) -> int:
     """Get the one-based index of the current step."""
     return await self.backend.get_current_step_index(**backend_kwargs)
 
   async def get_total_step_count(self, **backend_kwargs) -> int:
-    """Get the total number of steps in the current cycle."""
-    return await self.backend.get_total_step_count(**backend_kwargs)
+    """Get the total number of steps in the current protocol."""
+    return self._total_step_count
 
   async def wait_for_block(self, timeout: float = 600, tolerance: float = 0.5, **backend_kwargs):
     """Wait until block temp reaches target ± tolerance for all zones."""
@@ -234,22 +250,23 @@ async def wait_for_block(self, timeout: float = 600, tolerance: float = 0.5, **b
     raise TimeoutError("Block temperature timeout.")
 
   async def wait_for_lid(self, timeout: float = 1200, tolerance: float = 0.5, **backend_kwargs):
-    """Wait until the lid temperature reaches target ± ``tolerance`` or the lid temperature status is idle/holding at target."""
+    """Wait until the lid temperature reaches target ± ``tolerance`` or the lid status indicates it is ready."""
     try:
       targets = await self.get_lid_target_temperature(**backend_kwargs)
     except RuntimeError:
       targets = None
+
     start = time.time()
     while time.time() - start < timeout:
+      status = await self.get_lid_status(**backend_kwargs)
+      if status in [LidStatus.IDLE, LidStatus.HOLDING_AT_TARGET, "idle", "holding at target"]:
+        return
+
       if targets is not None:
         currents = await self.get_lid_current_temperature(**backend_kwargs)
         if all(abs(current - target) < tolerance for current, target in zip(currents, targets)):
           return
-      else:
-        # If no target temperature, check status
-        status = await self.get_lid_status(**backend_kwargs)
-        if status in ["idle", "holding at target"]:
-          return
+
       await asyncio.sleep(1)
     raise TimeoutError("Lid temperature timeout.")
 
@@ -261,15 +278,22 @@ async def is_profile_running(self, **backend_kwargs) -> bool:
     step = await self.get_current_step_index(**backend_kwargs)
     total_steps = await self.get_total_step_count(**backend_kwargs)
 
-    # if still holding in a step, it's running
+    # If still holding in a step, it is running.
     if hold and hold > 0:
       return True
-    # if haven't reached last cycle (zero-based indexing)
-    if cycle < total_cycles - 1:
+
+    # Some backends report the completed step count after finishing.
+    if total_steps and step >= total_steps:
+      return False
+
+    # If we have not reached the last cycle, it is running.
+    if total_cycles and cycle < total_cycles - 1:
       return True
-    # last cycle but not last step (zero-based indexing)
-    if cycle == total_cycles - 1 and step < total_steps - 1:
+
+    # Last cycle but not last step.
+    if total_steps and cycle == total_cycles - 1 and step < total_steps - 1:
       return True
+
     return False
 
   async def wait_for_profile_completion(self, poll_interval: float = 60.0, **backend_kwargs):
diff --git a/pylabrobot/thermocycling/thermocycler_tests.py b/pylabrobot/thermocycling/thermocycler_tests.py
index db0d4821c6f..7f691c6a121 100644
--- a/pylabrobot/thermocycling/thermocycler_tests.py
+++ b/pylabrobot/thermocycling/thermocycler_tests.py
@@ -24,17 +24,13 @@ def mock_backend() -> MagicMock:
   mock.deactivate_lid = AsyncMock()
   mock.run_protocol = AsyncMock()
   mock.get_block_current_temperature = AsyncMock(return_value=[25.0])
-  mock.get_block_target_temperature = AsyncMock(return_value=None)
   mock.get_lid_current_temperature = AsyncMock(return_value=[25.0])
-  mock.get_lid_target_temperature = AsyncMock(return_value=None)
   mock.get_lid_open = AsyncMock(return_value=False)
   mock.get_lid_temperature_status = AsyncMock(return_value="idle")
   mock.get_block_status = AsyncMock(return_value="idle")
   mock.get_hold_time = AsyncMock(return_value=0.0)
   mock.get_current_cycle_index = AsyncMock(return_value=0)
-  mock.get_total_cycle_count = AsyncMock(return_value=0)
   mock.get_current_step_index = AsyncMock(return_value=0)
-  mock.get_total_step_count = AsyncMock(return_value=0)
   return mock
 
 
@@ -132,9 +128,9 @@ async def test_is_profile_running_logic(self):
     for hold, cycle, total_cycles, step, total_steps, expected in test_cases:
       self.tc.backend.get_hold_time.return_value = hold  # type: ignore
       self.tc.backend.get_current_cycle_index.return_value = cycle  # type: ignore
-      self.tc.backend.get_total_cycle_count.return_value = total_cycles  # type: ignore
+      self.tc._total_cycle_count = total_cycles
       self.tc.backend.get_current_step_index.return_value = step  # type: ignore
-      self.tc.backend.get_total_step_count.return_value = total_steps  # type: ignore
+      self.tc._total_step_count = total_steps
       print(f"Testing with hold={hold}, cycle={cycle}, total_cycles={total_cycles}, ")
       assert await self.tc.is_profile_running() is expected